Oxidative stress in response to high glucose levels in endothelial cells and in endothelial progenitor cells: Evidence for differential glutathione peroxidase-1 expression

摘要: Abstract Endothelial cells and endothelial progenitor (EPCs) play a key role in the pathogenesis of vascular disease. Both cell types are affected by oxidative stress but their susceptibility may be different. This study aimed to investigate antioxidative enzymes activated EPCs after high constant glucose exposure as compared (HUVECs). were incubated presence normal (5 mM) (25 mM) d -glucose, well l -glucose osmotic control for 48 96 h. After 48-hour viability was significantly decreased both HUVECs with ( p while HUVEC at 96 h too High induced significant increase reactive oxygen species (ROS) production 48 h; however, 96 h, decrease ROS These data suggest that have well-adaptive response sustained exposure. resistance levels might due increased expression activity glutathione peroxidase allowing better survival.