Vitamin E Attenuates the Degree of Histopathological Lung Damage Following Toluene Diisocyanate Administration in Rats

摘要: In the current study we used a rat model of bronchial hyperreactivity induced by intranasal administration toluene diisocyanate TDI in Wistar rats. Four experimental groups were formed: (TDI), control - ethyl acetate (C), vitamin E and (TDI+E) (M+E). Our aim was to evaluate efficiency Vitamin attenuating histopathological lesions lungs. The presence anti-TDI IgE antibodies demonstrated through passive cutaneous anaphylaxis assay. Histopathological analysis lung changes performed comparing degree peribronchiolar inflammation goblet cell percentage between different studied. results showed that rats sensitized presented severe airways, eosinophilic infiltration present mid bronchi, not limited central airways. Bronchial associated lymphoid tissue (BALT) hyperplasia perivascular lymphoplasmacytic infiltrate also identified, which is evidence chronic These consistent with inflammatory symptoms hyper-reactivity observed are similar those asthma patients. resulted statistical significant reduction cells mucosa decrease semiquantitative score, compared group, but without significance. data suggest could be beneficial effects individuals develop following exposure.