High-dose pyridoxine as an 'anti-stress' strategy.

摘要: Pyridoxine nutritional status has a significant and selective modulatory impact on central production of both serotonin GABA - neurotransmitters which control depression, pain perception, anxiety owing to the fact that decarboxylases produce these have relatively low affinity for pyridoxal phosphate (PLP). deficiency leads increased sympathetic outflow hypertension in rodents, possibly reflecting decreased neurotransmitters; conversely, supplemental pyridoxine lowers blood pressure many animal models hypertension, there is preliminary evidence antihypertensive activity humans as well. Additionally, physiological levels PLP interact with glucocorticoid receptors down-regulate their activity. Thus, high-dose pyridoxine, by amplifying tissue PLP, may be expected favorable certain dysphoric mental states, while diminishing output acting peripherally blunt corticosteroids. In light growing chronic dysphoria, particularly when accompanied hopelessness or cynicism, major negative morbidity mortality from wide range disorders, high intakes potential improve prognosis individuals. With respect cardiovascular health, reduction homocysteine should contribute this benefit. These predictions are consistent recent epidemiology correlating plasma risk vascular events overall survival.