Nanozyme: new horizons for responsive biomedical applications.

摘要: Nanozymes are nanomaterial-based artificial enzymes. By effectively mimicking catalytic sites of natural enzymes or harboring multivalent elements for reactions, nanozyme systems have successfully served as direct surrogates traditional catalysis. With the rapid development and ever-deepening understanding nanotechnology, nanozymes offer higher stability, ease modification lower manufacturing cost than protein Additionally, possess inherent nanomaterial properties, providing not only a simple substitute but also multimodal platform interfacing complex biologic environments. Recent extensive research has focused on designing various that responsive to one multiple substrates by tailored means. Catalytic activities can be regulated pH, H2O2 glutathione concentrations levels oxygenation in different microenvironments. Moreover, remotely-controlled via stimuli, including magnetic field, light, ultrasound, heat. Collectively, these factors adjusted maximize diagnostic therapeutic efficacies diseases biomedical settings. Therefore, integrating property nature systems, we anticipate stimuli-responsive will open up new horizons diagnosis, treatment, theranostics.