Biocompatible caramelized carbonaceous nanospheres supported paramagnetic ultrathin manganese oxide nanosheets via self-sacrificing reduction as a MRI contrast agent for liver imaging
作者： Weihua Guo , Yafei Qi , Yuqiang Zhang , Long Ma , Dexin Yu
DOI: 10.1016/J.CARBON.2016.09.030
关键词:
摘要: Abstract The elimination of nanoparticles remains the major roadblock to clinical translation. Caramelization reaction is a general type non-enzymatic browning reactions food caramels, products carbonaceous nanospheres can be considered safe for biological applications. Here, we report biocompatible caramelized supported paramagnetic ultrathin manganese oxide nanosheets via self-sacrificing reduction as liver MRI contrast agent and T 1 -weighted MR imaging, which are taken up by Kupffer cells resulting in high relaxivity rate. Mn 3 O 4 -caramelized (Mn -CNPs) were synthesized their characteristics agents investigated. relaxation rate (r ) -CNPs calculated 11.6 mM −1 s by concentrations nearly three times commercial Gd III -based complex at 3.0 T scanner, in vivo experiment shows that signals mouse increase 50.1% under imaging 4 h post-injection -CNPs. bio-distribution reveals equal pre-injection after 48 h. Therefore, used agents.
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