The AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) Trial: To Believe or Not to Believe?
DOI: 10.1016/J.JACC.2012.02.021
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摘要: The beneficial effect of lowering low-density lipoprotein cholesterol (LDL-C) in clinical trials ([1][1]) has transformed our ability to reduce cardiovascular risk. However, increasing recognition that many patients experience a event, despite the use LDL-C therapies,
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Allen J. Taylor, Hyun J. Lee, Lance E. Sullenberger, The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3. Current Medical Research and Opinion. ,vol. 22, pp. 2243- 2250 ,(2006) , 10.1185/030079906X148508
B. Greg Brown, Xue-Qiao Zhao, Alan Chait, Lloyd D. Fisher, Marian C. Cheung, Josh S. Morse, Alice A. Dowdy, Emily K. Marino, Edward L. Bolson, Petar Alaupovic, Jiri Frohlich, Leny Serafini, Ellen Huss-Frechette, Shari Wang, Debbie DeAngelis, Arthur Dodek, John J. Albers, Simvastatin and Niacin, Antioxidant Vitamins, or the Combination for the Prevention of Coronary Disease The New England Journal of Medicine. ,vol. 345, pp. 1583- 1592 ,(2001) , 10.1056/NEJMOA011090
Philip J Barter, Mark Caulfield, Mats Eriksson, Scott M Grundy, John JP Kastelein, Michel Komajda, Jose Lopez-Sendon, Lori Mosca, Jean-Claude Tardif, David D Waters, Charles L Shear, James H Revkin, Kevin A Buhr, Marian R Fisher, Alan R Tall, Bryan Brewer, None, Effects of Torcetrapib in Patients at High Risk for Coronary Events The New England Journal of Medicine. ,vol. 357, pp. 2109- 2122 ,(2007) , 10.1056/NEJMOA0706628
Stephen J. Nicholls, High-density lipoprotein and progression rate of atherosclerosis in intravascular ultrasound trials. American Journal of Cardiology. ,vol. 104, pp. 16- ,(2009) , 10.1016/J.AMJCARD.2009.09.015
M. H. Luria, D. Sapoznikov, Raising HDL cholesterol with low-dose nicotinic acid and bezafibrate : preliminary experience Postgraduate Medical Journal. ,vol. 69, pp. 296- 299 ,(1993) , 10.1136/PGMJ.69.810.296
Tavia Gordon, William P. Castelli, Marthana C. Hjortland, William B. Kannel, Thomas R. Dawber, High density lipoprotein as a protective factor against coronary heart disease The American Journal of Medicine. ,vol. 62, pp. 707- 714 ,(1977) , 10.1016/0002-9343(77)90874-9
Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. JAMA. ,vol. 302, pp. 412- 423 ,(2009) , 10.1001/JAMA.2009.1063
Justin M.S. Lee, Matthew D. Robson, Ly-Mee Yu, Cheerag C. Shirodaria, Colin Cunnington, Ilias Kylintireas, Janet E. Digby, Thomas Bannister, Ashok Handa, Frank Wiesmann, Paul N. Durrington, Keith M. Channon, Stefan Neubauer, Robin P. Choudhury, Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study. Journal of the American College of Cardiology. ,vol. 54, pp. 1787- 1794 ,(2009) , 10.1016/J.JACC.2009.06.036
Paul L Canner, Kenneth G Berge, Nanette K Wenger, Jeremiah Stamler, Lawrence Friedman, Ronald J Prineas, William Friedewald, Coronary Drug Project Research Group, None, Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin Journal of the American College of Cardiology. ,vol. 8, pp. 1245- 1255 ,(1986) , 10.1016/S0735-1097(86)80293-5
B. Greg Brown, Xue-Qiao Zhao, Nicotinic acid, alone and in combinations, for reduction of cardiovascular risk. American Journal of Cardiology. ,vol. 101, ,(2008) , 10.1016/J.AMJCARD.2008.02.039