The p38 and JNK Pathways Cooperate to trans-Activate Vitamin D Receptor via c-Jun/AP-1 and Sensitize Human Breast Cancer Cells to Vitamin D3-induced Growth Inhibition *

作者: Xiaomei Qi , Rocky Pramanik , Jintang Wang , Richard M. Schultz , Ratan K. Maitra

DOI: 10.1074/JBC.M203039200

关键词:

摘要: … connection between the stress MAPK pathways and steroid … MAPK pathways through regulation of vitamin D 3 /VDR activity. … Because the Ras/ERK and the p38 MAPK pathways …

参考文章(74)
M. J. Birrer, T. K. Chen, Powel H Brown, Mechanism of action of a dominant-negative mutant of c-Jun. Oncogene. ,vol. 9, pp. 791- 799 ,(1994)
Angeline S. Andrew, Linda R. Klei, Aaron Barchowsky, AP-1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen. American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 281, ,(2001) , 10.1152/AJPLUNG.2001.281.3.L616
Daniel D. Bikle, Anita V. Ratnam, Cheryl D. Love-Schimenti, David F. C. Gibson, Antiestrogen potentiation of antiproliferative effects of vitamin D3 analogues in breast cancer cells. Cancer Research. ,vol. 56, pp. 2789- 2794 ,(1996)
K. Park, A. B. Roberts, M. B. Sporn, Hyun Bae, Seong-Jin Kim, G. P. Dotto, A. Heydemann, The E1A Oncogene Induces Resistance to the Effects of 1,25-Dihydroxyvitamin D3 on Inhibition of Growth of Mouse Keratinocytes Cancer Research. ,vol. 54, pp. 6087- 6089 ,(1994)
R.J. Wiese, A Uhland-Smith, T.K. Ross, J.M. Prahl, H.F. DeLuca, Up-regulation of the vitamin D receptor in response to 1,25-dihydroxyvitamin D3 results from ligand-induced stabilization. Journal of Biological Chemistry. ,vol. 267, pp. 20082- 20086 ,(1992) , 10.1016/S0021-9258(19)88668-4
M. Cavigelli, W. W. Li, A. Lin, B. Su, K. Yoshioka, M. Karin, The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. The EMBO Journal. ,vol. 15, pp. 6269- 6279 ,(1996) , 10.1002/J.1460-2075.1996.TB01017.X
Chen Wang, Li Deng, Mei Hong, Giridhar R Akkaraju, Jun-ichiro Inoue, Zhijian J Chen, None, TAK1 is a ubiquitin-dependent kinase of MKK and IKK Nature. ,vol. 412, pp. 346- 351 ,(2001) , 10.1038/35085597
A. Migliaccio, M. Di Domenico, G. Castoria, A. de Falco, P. Bontempo, E. Nola, F. Auricchio, Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. The EMBO Journal. ,vol. 15, pp. 1292- 1300 ,(1996) , 10.1002/J.1460-2075.1996.TB00471.X