A glutamate receptor antagonist, S-4-carboxyphenylglycine (S-4-CPG), inhibits vasospasm after subarachnoid hemorrhage in haptoglobin 2 to 2 mice

作者: Jacob J. Ruzevick , Matthew Bender , Lindsay Edwards , Rachel Grossman , Ming Zhao

DOI: 10.1227/NEU.0000000000000080

关键词:

摘要: Background Vasospasm contributes to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage (aSAH). Glutamate concentrations increase aSAH and correlate with vasospasm in experimental SAH. The Hp2-2 genotype is associated higher risk of We tested the efficacy S-4-CPG, a metabotropic glutamate receptor inhibitor, for treatment SAH Hp1-1 mice.

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