Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer

摘要: Cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase-2 (NOS-2) each have an important role in angiogenesis. The expression of these genes was investigated human prostate cancer by immunohistochemistry, the COX-1 COX-2 being confirmed mRNA analysis. Prostate specimens from 12 patients were compared to control prostates 13 operated on for bladder carcinoma. intensity NOS-2 immunostaining significantly stronger cells than non-malignant glandular epithelium prostates. clearly also expressed lesions prostatic intraepithelial neoplasia (PIN) detected muscle fibres hyperplastic stroma some No significant difference between These results indicate that is elevated adenocarcinoma PIN.