The role of leptin and orexins in the dysfunction of hypothalamo-pituitary-gonadal regulation and in the mechanism of hyperactivity in patients with anorexia nervosa.

摘要: Anorexia nervosa (AN) belongs to a group of eating disorders and is characterized by extreme body weight loss. AN patients show combination physical, psychological behavioral disturbances. Neuropeptides partly control energy homeostasis modulate hormone release. Leptin, peptide secreted adipocytes, may influence the interactions between central peripheral signals. Hypoleptinaemia found in connected with disturbed appetite hormonal dysfunction as well has implications for hypothalamo-pituitary-gonadal axis, bone mineral density physical hyperactivity. Low leptin levels are increased refeeding. However, prolonged hypoleptinaemia recovered result persistent hypothalamic amenorrhoea. The hyperactivity been observed 31-80 % cases. mechanisms underlying anorexia seem be more complicated many factors including neuropeptides involved. Orexins affect not only but also behavior psychophysical activity they regulate reproductive stress secretion, stimulate variety stereotypic behaviors reaction, hypothalamo-pituitary-adrenal (HPA) alter glucocorticoid catecholamine secretion activate sympathetic nervous system. mechanism regulating arousal sleep, cardiovascular function, temperature, metabolic rate locomotive activity. It worth considering how abnormal or their receptors play role hyperactivity, nervosa.