Synthesis of 4H-1,3-Benzoxazines via Metal- and Oxidizing Reagent-Free Aromatic C-H Oxygenation.
作者： Fan Xu , Xiang-Yang Qian , Yan-Jie Li , Hai-Chao Xu
DOI: 10.1021/ACS.ORGLETT.7B03152
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摘要: An unprecedented electrochemical aromatic C–H oxygenation reaction for the synthesis of 4H-1,3-benzoxazines from easily available N-benzylamides is reported. These oxidative cyclization reactions proceed in a transition metal- and oxidizing reagent-free fashion produce H2 as only theoretical byproduct. Adapting an microreactor has been demonstrated.
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