Rapid disorganization of mechanically interacting systems of mammary acini

摘要: Cells and multicellular structures can mechanically align concentrate fibers in their ECM environment sense respond to mechanical cues by differentiating, branching, or disorganizing. Here we show that mammary acini with compromised structural integrity interconnect forming long collagen lines. These lines then coordinate accelerate transition an invasive phenotype. Interacting begin disorganize within 12.5 ± 4.7 h a spatially coordinated manner, whereas do not interact other more slowly (in 21.8 4.1 h) lesser extent (P < 0.0001). When the directed connections between were cut laser, reverted disorganizing fully isolated from also bulk gel box-cuts side length <900 μm, phenotype was blocked 20 of experiments, regardless waiting time. Thus, pairs groups over distances through matrix, these interactions facilitate