Novel radioisotope-based nanomedical approaches

摘要: Radioisotope therapy of cancer is on the rise applying mainly β-emitting radionuclides. However, due to exposure healthy tissues, maximum achievable radiation dose with these limited. Auger-electron emitters (AEs) represent a promising alternative because their mode decay within short nanometer range. The challenge that therapeutic efficacy relies close vicinity DNA. To overcome this and minimize toxicity, construction smart nanomedical devices required, which ascertain tumor cell targeting succeeding cellular uptake nuclear translocation. In review we describe potential AEs focus delivery down DNA level effects. Reported efforts comprise different tumor-targeting strategies, including use antibodies or peptides localizing sequences. Recently, attention has shifted various nanoparticle formats for overcoming problems. end, approaches have mostly been tested in lines vitro more suited imaging than therapy. This defines demand formulations documented vivo activity, using selected come closer real clinical settings.