Differential Activation of IFN Regulatory Factor (IRF)-3 and IRF-5 Transcription Factors during Viral Infection
作者： Tsu-Fan Cheng , Sabrina Brzostek , Osamu Ando , Sarah Van Scoy , K. Prasanna Kumar
DOI: 10.4049/JIMMUNOL.176.12.7462
关键词:
摘要: Members of the IFN regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. Although related by homology at their N-terminal DNA-binding domain, they display individual functional properties. The distinct properties result from differences in regulated expression, response to activating signals, and interaction with DNA regulatory elements. IRF-3 is expressed ubiquitously and is activated by serine phosphorylation in response to viral infection or TLR signaling. Evidence …
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