Combination chemotherapy with 4′Demethylepipodophyllotoxin 9-(4,6-0-ethylidene-β-d-glucopyranoside), VP 16–213 (NSC 141540) in L1210 Leukemia☆

摘要: Abstract The epipodophyllotoxin derivative VP 16–213 (NSC 141540), an antineoplastic agent of high activity against transplantable leukemia in mice and proven human tumours, was studied combination therapy with actinomycin D, 1,3-bis(2-chloro-ethyl)-1-nitrosourea (BCNU), cyclophosphamide (CTX), cytosine arabinoside, daunorubicin, 5-fluorouracil, 6-mercaptopurine, methotrexate or vincristine L1210 mice. With one treatment on day 1 after transplantation, the therapeutic results vincristine, were same range inferior to effect single agents. Combination CTX BCNU led remarkably good results, which “more than additive” type. Thus, equitoxic doses, for example, 16–213+CTX (ratio 1:1) at 0·5 ld 10 level gave 75% cures compared 5% alone 0% CTX. When started 6 no advantage could be demonstrated, while 16–213+BCNU still proved superior agents, respect increase life-span cure rate.