A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population

摘要: Chromogranin A (CHGA) is a major protein in the secretory granules of chromaffin cells. CHGA also gives rise to cardiovascular/metabolism regulatory peptides, such as catestatin (CST) and pancreastatin (PST). While CST potent inhibitor catecholamine secretion, PST physiological glucose-induced insulin secretion. Recently, several SNPs were identified domains locus different populations. Among discovered SNPs, variant allele Ser-364 was associated with blood pressure alteration Ser-297 significantly higher plasma glucose level. In this study, we examined whether these alleles exist influence cardiovascular metabolic phenotypes Japanese population. Our study comprised 343 subjects aged 45-85 years (143 men 200 women, mean age 66 ± 8 years). We determined genotypes by PCR-direct sequencing method carried out genotype-phenotype association analysis. participants, minor frequency 6.10%. On other hand, did not detect entire The presence increased baPWV (an index systemic arterial stiffness) that suggests an initiation and/or progression atherogenesis hypertension. elevated systolic pulse pressure, consistent baPWV. conclusion, may increase risk for diseases