Apoptogenic activity of two benzophenanthridine alkaloids from Chelidonium majus L. does not correlate with their DNA damaging effects.
作者： Alex Philchenkov , Vitaliy Kaminskyy , Michael Zavelevich , Rostyslav Stoika
DOI: 10.1016/J.TIV.2007.08.023
关键词:
摘要: Apoptogenic and DNA damaging effects of chelidonine (CHE) sanguinarine (SAN), two structurally related benzophenanthridine alkaloids isolated from Chelidonium majus L. (Papaveraceae), were compared. Both induced apoptosis in human acute T-lymphoblastic leukaemia MT-4 cells. Apoptosis induction by CHE SAN these cells was accompanied caspase-9 -3 activation an increase the pro-apoptotic Bax protein. An elevation percentage possessing caspase-3 active form after their treatment with or parallel to a corresponding fraction apoptotic The involvement mitochondria both supported cytochrome C cytosol, accompanying decrease content mitochondrial fraction. At same time, under study differed drastically cell cycle phase-specific effects, since only arrested G(2)/M phase. It shown earlier, that CHE, contrast SAN, does not interact directly DNA. This fact is line detected COMET assay. Nevertheless, apoptosis-inducing activity even slightly exceeded SAN.
elsevier.com
sci-hub.se 参考文章(25)
Max Mano, Vinorelbine in the management of breast cancer: New perspectives, revived role in the era of targeted therapy Cancer Treatment Reviews. ,vol. 32, pp. 106- 118 ,(2006) , 10.1016/J.CTRV.2005.12.008
A. Philchenkov, Caspases: potential targets for regulating cell death Journal of Cellular and Molecular Medicine. ,vol. 8, pp. 432- 444 ,(2004) , 10.1111/J.1582-4934.2004.TB00468.X
J Lenfeld, MARSALEK Kroutil, E Maršálek, J Slavik, V Preininger, V Šimánek, None, Antiinflammatory Activity of Quaternary Benzophenanthridine Alkaloids from Chelidonoum majus Planta Medica. ,vol. 43, pp. 161- 165 ,(1981) , 10.1055/S-2007-971493
Rong Yu, Sandhya Mandlekar, Tse-Hua Tan, A.-N. Tony Kong, Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. Journal of Biological Chemistry. ,vol. 275, pp. 9612- 9619 ,(2000) , 10.1074/JBC.275.13.9612
Ádám Kemény-Beke, János Aradi, Judit Damjanovich, Zoltán Beck, Andrea Facskó, András Berta, Andrea Bodnár, Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine Cancer Letters. ,vol. 237, pp. 67- 75 ,(2006) , 10.1016/J.CANLET.2005.05.037
Franco Zunino, Graziella Pratesi, Camptothecins in clinical development. Expert Opinion on Investigational Drugs. ,vol. 13, pp. 269- 284 ,(2004) , 10.1517/13543784.13.3.269
Gary L. Peterson, A simplification of the protein assay method of Lowry et al. which is more generally applicable Analytical Biochemistry. ,vol. 83, pp. 346- 356 ,(1977) , 10.1016/0003-2697(77)90043-4
Razqallah Hakem, Anne Hakem, Gordon S Duncan, Jeffrey T Henderson, Minna Woo, Maria S Soengas, Andrew Elia, José Luis de la Pompa, David Kagi, Wilson Khoo, Julia Potter, Ritsuko Yoshida, Stephen A Kaufman, Scott W Lowe, Josef M Penninger, Tak W Mak, Differential requirement for caspase 9 in apoptotic pathways in vivo Cell. ,vol. 94, pp. 339- 352 ,(1998) , 10.1016/S0092-8674(00)81477-4
Hasan Mukhtar, Sanjay Gupta, Nihal Ahmad, Kaisa M. Heiskanen, Mirza M. Husain, Differential Antiproliferative and Apoptotic Response of Sanguinarine for Cancer Cells versus Normal Cells Clinical Cancer Research. ,vol. 6, pp. 1524- 1528 ,(2000)
David J. Newman, Gordon M. Cragg, Kenneth M. Snader, Natural Products as Sources of New Drugs over the Period 1981−2002 Journal of Natural Products. ,vol. 66, pp. 1022- 1037 ,(2003) , 10.1021/NP030096L