Gene therapy in peripheral artery disease

摘要: Introduction: Despite the remarkable progress of medicine and endovascular procedures for revascularization, patients with critical limb ischemia (CLI) remain at high risk amputation often have a low quality life due to pain ulcers in ischemic leg. Thus, novel strategy generating new blood vessels CLI without treatment options is vital. Pre-clinical studies Phase I clinical trials using VEGF fibroblast growth factor (FGF) demonstrated promising results; however, more rigorous II III failed demonstrate benefits patients. Recently, two multicenter, double-blind, placebo-controlled Japan (Phase III) USA II) showed hepatocyte (HGF) gene therapy Although number included these was relatively small, results imply distinct beneficial function HGF over other angiogenic factors setting.Areas cove...