CAPN3, DCT, MLANA and TYRP1 are overexpressed in skin of vitiligo vulgaris Mexican patients.

摘要: Vitiligo is a disorder causing skin depigmentation, in which several factors have been proposed for its pathogenesis: Environmental, genetic and biological aspects of melanocytes, even those the surrounding keratinocytes. However, lack understanding mechanisms has complicated task predicting development progression. The present study used microarray analysis to characterize transcriptional profile from Vulgaris (VV) patients identified transcripts were validated using targeted high-throughput RNA sequencing broader set patients. For microarrays, mRNA was taken 20 biopsies 10 with VV (pigmented depigmented biopsy each), 5 healthy subjects matched age sex as control. A signature that contains expression pattern 722 genes between vitiligo vs. control, 1,108 pigmented controls 1,927 skin, (P<0.05; false discovery rate, <0.1). When comparing vitiligo, reflects real difference both types, differentially expressed further 45 additional by sequencing. This showed significantly higher levels calpain-3, dopachrome tautomerase, melan-A tyrosinase-related protein-1 genes. data revealed already affected at level gene main differences non-pigmented are explained associated pigment metabolism.