On the Estimation of Additive Interaction by Use of the Four-by-two Table and Beyond

摘要: A four-by-two table with its four rows representing the presence and absence of gene environmental factors has been suggested as fundamental unit in assessment gene-environment interaction. For such a to be more meaningful from public health perspective, it is important estimate additive confidence interval procedure proposed by Hosmer Lemeshow become widespread. This article first reveals that Hosmer-Lemeshow makes an assumption intervals for risk ratios are symmetric then presents alternative uses conventional asymmetric set limits measures table, calculation involved requires no statistical programs but only elementary calculations. Simulation results demonstrate this new approach can perform almost well bootstrap. Corresponding calculations complicated situations simplified use routine output multiple regression programs. The illustrated three examples. Microsoft Excel spreadsheet SAS codes available author Journal's website, respectively.