A New Method for Synthesis of Nucleoside 3', 5'-Cyclic Phosphates. Cyclization of Nucleoside 5'-Trichloromethylphosphonates

摘要: The reaction of various nucleosides (III) with trichloromethylphosphonic acid dichloride in triethyl phosphate or m-cresol afforded nucleoside 5'-trichloromethylphosphonates (IV). intramolecular cyclization IV potassium t-butoxide dimethyl sulfoxide N, N-dimethylformamide led to the synthesis 3', 5'-cyclic phosphates (I) high yields by fission C-P bond phosphonate