Assessment of the safety of Bacillus Calmette-Guérin vaccine administered orally to badgers (Meles meles).

摘要: Abstract European badgers ( Meles meles ) are a wildlife reservoir for Mycobacterium bovis M. in parts of England, Wales and Ireland, constituting potential source tuberculosis (TB) infection cattle. Vaccination against TB is one the tools available helping reduce prevalence bovine badgers, made possible by licensing 2010 Bacillus Calmette-Guerin (BCG) vaccine intramuscular administration to (BadgerBCG). However, practical limitations associated with administering an injected wild animals make oral, bait-delivered form highly desirable. Evaluation safety oral BCG environment mandatory step on road vaccine. This study had following objectives: (a) determine whether adverse effects followed badgers; (b) measure quantity frequency excreted faeces vaccinated (c) assess there was evidence spreading unvaccinated, ‘sentinel’ sharing same as animals. We report here that per badger of ≥6.4 × 10 9  cfu BCG, 14 days later single dose ≥6.4 × 10 7 caused no physical did not affect social behaviour feeding habits cultured from two nine (372 cfu/g 996 cfu/g, respectively) approximately 48 h after higher administered animal (80 cfu/g) 24 h receiving lower BCG. found transmission sentinel, housed despite occasional excretion faeces.