Brain Tumor Therapy with Antisense Oligonucleotides

摘要: Antisense oligonucleotides (AON), short of DNA, which selectively bind to complementary mRNA inside the cytoplasm, can specifically block genes and production designated proteins. The use AP12009 against TGF-β2 has been most frequently studied antisense therapy for brain tumors so far. Further oncogenes e.g. c-Met, RAS or Bcl-2, growth factors VEGF, EGFR, IGF-1 enzyme telomerase have suggested as such targets. Other strategies deal with an immunological approach AON CpG motifs. Systemic is limited by its degradation in plasma and, case tumors, blood–brain-barrier. Many studies these problems a construction modified AON, coupling liposomes nanoparticles direct administration into via convection-enhanced delivery. All are promising options, but currently foreseeable future there no cure malignant glioma single therapeutical regime. Possibly combination several may be more effective cruel tumors.