Whole Genome Expression Analyses of miRNAs and mRNAs Suggest the Involvement of miR-320a and miR-155-3p and their Targeted Genes in Lithium Response in Bipolar Disorder.
作者： Pisanu , Merkouri Papadima , Melis , Congiu , Loizedda
DOI: 10.3390/IJMS20236040
关键词:
摘要: Lithium is the mainstay in maintenance of bipolar disorder (BD) and most efficacious pharmacological treatment suicide prevention. Nevertheless, its use hampered by a high interindividual variability important side effects. Genetic epigenetic factors have been suggested to modulate lithium response, but findings so far not allowed identifying molecular targets with predictive value. In this study we used next generation sequencing measure genome-wide miRNA expression lymphoblastoid cell lines from BD patients excellent responders (ER, n = 12) non-responders (NR, lithium. These data were integrated microarray identify pairs miRNA/mRNA inversely significantly correlated. Significant prioritized based on strength association in-silico target prediction analyses select candidates for validation qRT-PCR. Thirty-one miRNAs differentially expressed ER vs. NR correlated 418 genes between two groups. A total 331 these correlations also predicted algorithms. miR-320a miR-155-3p, as well three their targeted (CAPNS1 (Calpain Small Subunit 1) RGS16 (Regulator G Protein Signaling 16) miR-320, SP4 (Sp4 Transcription Factor) miR-155-3p) validated. mRNAs previously implicated psychiatric disorders (miR-320a SP4), key processes central nervous system (CAPNS1, RGS16, SP4) or pathways involved mental illnesses (miR-155-3p). Using an approach, identified potentially response BD.
mdpi.com
sci-hub.se 参考文章(59)
M. Fornaro, B. Stubbs, D. De Berardis, F. Iasevoli, M. Solmi, N. Veronese, A. Carano, G. Perna, A. De Bartolomeis, Does the "Silver Bullet" Lose its Shine Over the Time? Assessment of Loss of Lithium Response in a Preliminary Sample of Bipolar Disorder Outpatients. Clinical Practice & Epidemiology in Mental Health. ,vol. 12, pp. 142- 157 ,(2016) , 10.2174/1745017901612010142
Pierre A. Geoffroy, Emmanuel Curis, Cindie Courtin, Jeverson Moreira, Thomas Morvillers, Bruno Etain, Jean-Louis Laplanche, Frank Bellivier, Cynthia Marie-Claire, Lithium response in bipolar disorders and core clock genes expression. World Journal of Biological Psychiatry. ,vol. 19, pp. 619- 632 ,(2018) , 10.1080/15622975.2017.1282174
M. Budde, D. Degner, J. Brockmöller, T.G. Schulze, Pharmacogenomic aspects of bipolar disorder: An update European Neuropsychopharmacology. ,vol. 27, pp. 599- 609 ,(2017) , 10.1016/J.EURONEURO.2017.02.001
Gabriele Sani, Giulio Perugi, Leonardo Tondo, Treatment of Bipolar Disorder in a Lifetime Perspective: Is Lithium Still the Best Choice? Clinical Drug Investigation. ,vol. 37, pp. 713- 727 ,(2017) , 10.1007/S40261-017-0531-2
Kaoru Goto, Masao Doi, Tianyu Wang, Sumihiro Kunisue, Iori Murai, Hitoshi Okamura, G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review]. Endocrine Journal. ,vol. 64, pp. 571- 579 ,(2017) , 10.1507/ENDOCRJ.EJ17-0130
Eleni Merkouri Papadima, Paola Niola, Carla Melis, Claudia Pisanu, Donatella Congiu, Cristiana Cruceanu, Juan Pablo Lopez, Gustavo Turecki, Raffaella Ardau, Giovanni Severino, Caterina Chillotti, Maria Del Zompo, Alessio Squassina, None, Evidence towards RNA Binding Motif (RNP1, RRM) Protein 3 (RBM3) as a Potential Biomarker of Lithium Response in Bipolar Disorder Patients Journal of Molecular Neuroscience. ,vol. 62, pp. 304- 308 ,(2017) , 10.1007/S12031-017-0938-5
Claudia Pisanu, Donatella Congiu, Carla Melis, Giovanni Severino, Andrea Angius, Raffaella Ardau, Caterina Chillotti, Maria Del Zompo, Alessio Squassina, Involvement of core clock genes in lithium response. World Journal of Biological Psychiatry. ,vol. 19, pp. 645- 646 ,(2018) , 10.1080/15622975.2017.1346281
Thomaz Oliveira, Victor Marinho, Valécia Carvalho, Francisco Magalhães, Kaline Rocha, Carla Ayres, Silmar Teixeira, Monara Nunes, Victor Hugo Bastos, Giovanny R Pinto, Genetic polymorphisms associated with circadian rhythm dysregulation provide new perspectives on bipolar disorder Bipolar Disorders. ,vol. 20, pp. 515- 522 ,(2018) , 10.1111/BDI.12624
Michele Fornaro, Annalisa Anastasia, Francesco Monaco, Stefano Novello, Andrea Fusco, Felice Iasevoli, Domenico De Berardis, Nicola Veronese, Marco Solmi, Andrea de Bartolomeis, Clinical and psychopathological features associated with treatment-emergent mania in bipolar-II depressed outpatients exposed to antidepressants. Journal of Affective Disorders. ,vol. 234, pp. 131- 138 ,(2018) , 10.1016/J.JAD.2018.02.085
Andreas J Forstner, Julian Hecker, Janice M Fullerton, Per Hoffmann, Liping Hou, Urs Heilbronner, Franziska Degenhardt, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Raffaella Ardau, BA Rbara Arias, Lena Backlund, Antonio Benabarre, Susanne Bengesser, Abesh K Bhattacharjee, Joanna M Biernacka, Armin Birner, Cynthia Marie-Claire, Pablo Cervantes, Guo-Bo Chen, Hsi-Chung Chen, Caterina Chillotti, Scott R Clark, Francesc Colom, David A Cousins, Cristiana Cruceanu, Piotr M Czerski, Alexandre Dayer, Bruno Atain, Peter Falkai, Louise FrisA, Julie S Garnham, Fernando S Goes, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Esther JimA, Jean-Pierre Kahn, Layla Kassem, Sarah Kittel-Schneider, Sebastian Kliwicki, KA Barbara, Ichiro Kusumi, Nina Lackner, Gonzalo Laje, Mikael LandA, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, A Carlos, Pez Jaramillo, Glenda MacQueen, Mirko Manchia, Lina Martinsson, Manuel Mattheisen, Michael J McCarthy, Susan L McElroy, Marina Mitjans, Francis M Mondimore, Palmiero Monteleone, Caroline M Nievergelt, Urban Asby, Norio Ozaki, Roy H Perlis, Andrea Pfennig, Daniela Reich-Erkelenz, Guy A Rouleau, Peter R Schofield, K Oliver Schubert, Barbara W Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D Shilling, Kazutaka Shimoda, Christian Simhandl, Claire M Slaney, Jordan W Smoller, Alessio Squassina, Thomas J Stamm, Pavla Stopkova, Sarah K Tighe, Alfonso Tortorella, Gustavo Turecki, Julia Volkert, Stephanie H Witt, Adam J Wright, L Trevor Young, Peter P Zandi, James B Potash, J Raymond DePaulo, Michael Bauer, Eva Reininghaus, Jean-Michel Aubry, Mario Maj, Bernhard T Baune, Philip B Mitchell, Eduard Vieta, Mark A Frye, Janusz K Rybakowski, Po-Hsiu Kuo, Tadafumi Kato, Maria Grigoroiu-Serbanescu, Andreas Reif, Maria Del Zompo, Frank Bellivier, Martin Schalling, Naomi R Wray, John R Kelsoe, Martin Alda, Francis J McMahon, Thomas G Schulze, Marcella Rietschel, M Markus, Sven Cichon, None, Analysis of the influence of microRNAs in lithium response in bipolar disorder Frontiers in Psychiatry. ,vol. 9, pp. 207- 207 ,(2018) , 10.3389/FPSYT.2018.00207