Skeletal myogenic potential of human and mouse neural stem cells.

摘要: Distinct cell lineages established early in development are usually maintained throughout adulthood. Thus, adult stem cells have been thought to generate differentiated specific the tissue which they reside. This view has challenged; for example, neural can that normally originate from a different germ layer. Here we show acutely isolated and clonally derived mice humans could produce skeletal myotubes vitro vivo, latter following transplantation into animals. Myogenic conversion required direct exposure myoblasts, was blocked if were clustered. community effect between may override such myogenic induction. We conclude cells, neurons, glia blood also muscle undergo various patterns of differentiation depending on appropriate epigenetic signals mature tissues.