Management of unresectable malignant endocrine tumors of the pancreas.

摘要: Malignant endocrine tumors of the pancreas are a heterogenous group with multipotential secretory capacity. The lesions generally slow growing relatively long life expectancy from time diagnosis. Death results combination local and metastatic disease sequelae excess hormone secretion. While potentially successful curative resections rare, term survival is frequently possible based on rate growth inhibition bioactive effects products tumor. Regional control palliative surgical debulking transcatheter arterial embolization hepatic metastases has an important role in terms symptomatic relief survival. These respond to chemotherapy. Combination chemotherapy more effective than single agent treatment. Preliminary information suggests that leukocyte interferon useful treatment, but this still requires careful prospective evaluation. current data do not support use octreotide for antitumor effect, it capable producing prompt substantial minimal side large proportion patients functional malignant pancreas. Many advances have been made recognition, diagnosis management Additional basic cellular research necessary define molecular cell biologic factors these tumor cells. Particular facets require further understanding include their cytogenetic abnormality, regulation peptide production peptides other endocrine, paracrine autocrine regulatory relationships. answers questions will hopefully promulgate discovery improved cytotoxic agents, better pharmacotherapeutic agents improve overall unresectable