Application of capillary electrophoresis to pharmaceutical analysis

摘要: A method using capillary electrophoresis (CE) for the determination of alendronate (a non-chromophoric compound) in pharmaceutical dosage forms is described. Direct UV detection based on on-line formation a chromophoric complex between and Cu2+ ions present electrolyte solution. The CE has been validated to address quantitative aspects practical applications. Tablet can be suitably assayed by proposed method. Analysis intravenous solutions encounters interference from citrate anion, strong metal-chelating agent, formulation, resulting low irreproducible assay results. developed obviates any derivatization procedure involves minimum sample preparation