Deregulation of miR-126 expression in colorectal cancer pathogenesis and its clinical significance
作者： Faeza Ebrahimi , Vinod Gopalan , Riajul Wahab , Cu-Tai Lu , Robert Anthony Smith
DOI: 10.1016/J.YEXCR.2015.10.004
关键词:
摘要: In this study, we investigated the expression profiles and clinicopathological significance of miR-126 in large cohort patients with colorectal cancers as well cellular repercussions colon cancer cells along its targets in-vitro. Down regulation was associated histological subtypes, peri-neural tumour infiltration, microsatellite instability pathological staging (p<0.05). Low also poorer survival cancer. Analysis matched tissues from same patient revealed that approximately 70% tested had similar levels primary metastases both lymph node distant metastases. addition, induced overexpression showed reduced cell proliferation, increased apoptosis decreased accumulation G0-G1 phase cells. Furthermore, SW480(+miR-126) BCL-2 P53 protein expression. To conclude, deregulation at tissue correlation various parameters confirm suppressive role
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Jianning Song, Zhigang Bai, Hua Meng, Yao Yang, Yun Yang, Weirong Li, Jun Zhang, Jie Yin, Xuemei Ma, Tingting Wang, Jin Wang, Wei Han, Zhongtao Zhang, Differential expression of serum miR-126, miR-141 and miR-21 as novel biomarkers for early detection of liver metastasis in colorectal cancer. Chinese Journal of Cancer Research. ,vol. 26, pp. 95- 103 ,(2014) , 10.3978/J.ISSN.1000-9604.2014.02.07
J G Batsakis, Nerves and neurotropic carcinomas. Annals of Otology, Rhinology, and Laryngology. ,vol. 94, pp. 426- 427 ,(1985)
Vinod Gopalan, Suja Pillai, Faeza Ebrahimi, Ali Salajegheh, Tommy C Lam, Tran K Le, Nicole Langsford, Yik‐Hong Ho, Robert A Smith, Alfred K‐Y Lam, None, Regulation of microRNA-1288 in Colorectal Cancer: Altered Expression and Its Clinicopathological Significance Molecular Carcinogenesis. ,vol. 53, ,(2014) , 10.1002/MC.21993
Catherine Liebig, Gustavo Ayala, Jonathan A. Wilks, David H. Berger, Daniel Albo, Perineural invasion in cancer: A review of the literature Cancer. ,vol. 115, pp. 3379- 3391 ,(2009) , 10.1002/CNCR.24396
Yaling Liu, Yu Zhou, Xiao Feng, Pengchun Yang, Jingfang Yang, Ping An, Hao Wang, Shicai Ye, Caiyuan Yu, Yanting He, Hesheng Luo, Low expression of microRNA-126 is associated with poor prognosis in colorectal cancer. Genes, Chromosomes and Cancer. ,vol. 53, pp. 358- 365 ,(2014) , 10.1002/GCC.22146
Sohail F. Tavazoie, Claudio Alarcón, Thordur Oskarsson, David Padua, Qiongqing Wang, Paula D. Bos, William L. Gerald, Joan Massagué, Endogenous human microRNAs that suppress breast cancer metastasis Nature. ,vol. 451, pp. 147- 152 ,(2008) , 10.1038/NATURE06487
Wei Wu, Identification of aberrantly expressed miRNAs in rectal cancer. Oncology Reports. ,vol. 28, pp. 77- 84 ,(2012) , 10.3892/OR.2012.1769
Naif AlQurashi, Vinod Gopalan, Robert A. Smith, Alfred King Y. Lam, Clinical impacts of mammalian target of rapamycin expression in human colorectal cancers Human Pathology. ,vol. 44, pp. 2089- 2096 ,(2013) , 10.1016/J.HUMPATH.2013.03.014
Vinod Gopalan, Robert A. Smith, Alfred K.-Y. Lam, Downregulation of microRNA-498 in colorectal cancers and its cellular effects Experimental Cell Research. ,vol. 330, pp. 423- 428 ,(2015) , 10.1016/J.YEXCR.2014.08.006
Nan Li, Anliu Tang, Shuo Huang, Zeng Li, Xiayu Li, Shourong Shen, Jian Ma, Xiaoyan Wang, MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway Molecular and Cellular Biochemistry. ,vol. 380, pp. 107- 119 ,(2013) , 10.1007/S11010-013-1664-0