Xanthonolol: A calcium channel and beta-adrenoceptor blocker with vasodilating properties

摘要: Abstract 1. Xanthonolol (0.1–0.5 mg/kg, i.v.) reduced the blood pressure, heart rate, and l -isoproterenol (0.05 μg/kg, i.v.)-induced tachycardia in rats. 2. In isolated guinea-pig right atrium, xanthonolol (10 −6 −3 × 10 −4 M) produced long-lasting negative, inhibited -isoproterenol-induced positive chronotropic effects, prevented rate-increasing effects of increased extracellular Ca 2+ (3.0–9.0 mM), mM)-induced rate-increase. 3. thoracic aorta, contractions induced by CaCl 2 (0.1–5.0 mM) were –10 M). 4. is suggested to have a calcium channel beta adrenergic blocking effect with vasodilating properties.