The TPR Motif as a Protein Interaction Module - A Discussion of Structure and Function

摘要: Many biological functions involve the formation of protein-protein complexes. Indeed, protein–protein interactions are considered to be center all functional living cells. Proteins can interact with each other by various structural, chemical and physical means. Some these highly specific, accompanied high affinity, while some proteins more flexible bind diverse as ligands. A common group that participate in serve multi-protein complex mediators tetra-trico-peptide repeat (TPR) proteins. TPR-containing were found involved many processes eukaryotic cells, including synaptic vesicle fusion (Young et al. 2003), peroxisomal targeting import (Brocard 2006; Fransen 2008) mitochondrial chloroplast (Baker 2007; Mirus 2009). In addition, TRPs required for bacterial pathways, such outer membrane assembly (Gatsos 2008), bio-mineralization iron oxides magnetotactic bacteria (Zeytuni 2011) pathogenesis ( Edqvist Tiwari mutations have been linked a variety human diseases, chronic granulomatous disease Leber’s congenital amaurosis (D'Andrea & Regan 2003).