Association between thyroid hormones and TRAIL.

摘要: Abstract Introduction Recent studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) might have role in the regulation of body weight and metabolism. Interestingly, thyroid hormones seem to increase tissue expression. This study aimed at evaluating whether overt disorders affected levels. Methods levels were measured euthyroid, hyperthyroid, hypothyroid patients before after function normalization. Univariate multivariate analyses performed evaluate correlation between TRAIL. Then, stimulatory effect both triiodothyronine (T3) thyroxine (T4) on was evaluated vitro peripheral blood mononuclear cells. Results Circulating significantly increased hyperthyroid decreased as compared controls. Once restored, normalized. There an independent association fT3 fT4. Consistent with these findings, T3 T4 stimulated release . Conclusion Here we show are associated expression vivo stimulate Given overlap metabolic effects TRAIL, this work sheds light possibility be one molecules mediating effects.