Interactions between Glucocorticoid Treatment and Cis-Regulatory Polymorphisms Contribute to Cellular Response Phenotypes

摘要: Glucocorticoids (GCs) mediate physiological responses to environmental stress and are commonly used as pharmaceuticals. GCs act primarily through the GC receptor (GR, a transcription factor). Despite their clear biomedical importance, little is known about genetic architecture of variation in response. Here we provide an initial assessment variability cellular response treatment by profiling gene expression protein secretion 114 EBV-transformed B lymphocytes African European ancestry. We found that affects nearby genes exhibits distinctive patterns genotype-treatment interactions, with genotypic effects evident either only GC-treated or control-treated conditions. Using novel statistical framework, identified interactions influence 26 play central roles GC-related pathways (e.g. NQO1, AIRE, SGK1) IL6.