Clinical characteristics and long-term outcomes of patients with heart failure and preserved systolic function

作者: Christopher M O’Connor , Wendy A Gattis , Linda Shaw , Michael S Cuffe , Robert M Califf

DOI: 10.1016/S0002-9149(00)01107-3

关键词:

摘要: Although the syndrome of heart failure with preserved systolic function may occur in up to 40% all patients, clinical, angiographic characteristics, and long-term outcomes these patients are poorly understood. We prospectively evaluated 2,498 consecutive New York Heart Association class II IV symptoms ejection fractions >40%, who underwent cardiac catheterization between January 1984 December 1996 at Duke University Medical Center. The median age for entire cohort was 63 years; 25% population >71 years old. In addition, 55% were women, 65% had ischemic disease, 28% a history diabetes, 62% hypertension. fraction 58%. One third multivessel disease by coronary angiography. overall 5-year mortality total 28%. independent predictors (p <0.05) using multivariable Cox proportional hazard model age, symptoms, fraction, artery index, peripheral vascular minority ethnic group. is characterized unique clinical characteristics associated rate Furthermore, several predictive survival.

参考文章(14)
Kent W. Dauterman, Barry M. Massie, Mihai Gheorghiade, Heart failure associated with preserved systolic function: A common and costly clinical entity American Heart Journal. ,vol. 135, pp. S310- S319 ,(1998) , 10.1016/S0002-8703(98)70258-3
Mary McGrae McDermott, Joe Feinglass, Peter I. Lee, Shruti Mehta, Brian Schmitt, Frank Lefevre, Mihai Gheorghiade, Systolic function, readmission rates, and survival among consecutively hospitalized patients with congestive heart failure. American Heart Journal. ,vol. 134, pp. 728- 736 ,(1997) , 10.1016/S0002-8703(97)70057-7
R O Bonow, S L Bacharach, M V Green, K M Kent, D R Rosing, L C Lipson, M B Leon, S E Epstein, Impaired left ventricular diastolic filling in patients with coronary artery disease: assessment with radionuclide angiography. Circulation. ,vol. 64, pp. 315- 323 ,(1981) , 10.1161/01.CIR.64.2.315
Mary McGrae McDermott, Joe Feinglass, Jeffrey Sy, Mihai Gheorghiade, Hospitalized congestive heart failure patients with preserved versus abnormal left ventricular systolic function: clinical characteristics and drug therapy. The American Journal of Medicine. ,vol. 99, pp. 629- 635 ,(1995) , 10.1016/S0002-9343(99)80250-2
Ramachandran S. Vasan, Congestive Heart Failure With Normal Left Ventricular Systolic Function Archives of Internal Medicine. ,vol. 156, pp. 146- 157 ,(1996) , 10.1001/ARCHINTE.1996.00440020046007
Arthur Dodek, Donald G. Kassebaum, J. David Bristow, Pulmonary Edema in Coronary-Artery Disease without Cardiomegaly New England Journal of Medicine. ,vol. 286, pp. 1347- 1350 ,(1972) , 10.1056/NEJM197206222862507
Peter Carson, Gary Johnson, Ross Fletcher, Jay Cohn, V-HeFT Cooperative Study Group, Mild systolic dysfunction in heart failure (left ventricular ejection fraction >35%): Baseline characteristics, prognosis and response to therapy in the vasodilator in heart failure trials (V-HeFT) Journal of the American College of Cardiology. ,vol. 27, pp. 642- 649 ,(1996) , 10.1016/0735-1097(95)00503-X
Ramachandran S. Vasan, Emelia J. Benjamin, Daniel Levy, Prevalence, clinical features and prognosis of diastolic heart failure: An epidemiologic perspective Journal of the American College of Cardiology. ,vol. 26, pp. 1565- 1574 ,(1995) , 10.1016/0735-1097(95)00381-9
D B Mark, C L Nelson, R M Califf, F E Harrell, K L Lee, R H Jones, D F Fortin, R S Stack, D D Glower, L R Smith, Continuing evolution of therapy for coronary artery disease. Initial results from the era of coronary angioplasty. Circulation. ,vol. 89, pp. 2015- 2025 ,(1994) , 10.1161/01.CIR.89.5.2015
Linda P. Fried, Nemat O. Borhani, Paul Enright, Curt D. Furberg, Julius M. Gardin, Richard A. Kronmal, Lewis H. Kuller, Teri A. Manolio, Maurice B. Mittelmark, Anne Newman, Daniel H. O'Leary, Bruce Psaty, Pentti Rautaharju, Russell P. Tracy, Philip G. Weiler, The cardiovascular health study: Design and rationale Annals of Epidemiology. ,vol. 1, pp. 263- 276 ,(1991) , 10.1016/1047-2797(91)90005-W