Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin
作者： Alfred J. Lewy , Brant P. Hasler , Jonathan S. Emens , Robert L. Sack
DOI: 10.1016/S0304-3940(01)02261-3
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摘要: To date, we have entrained (synchronized) eight totally blind people with free-running circadian rhythms to a nightly dose of 10 mg melatonin. Each person at different phase angle entrainment (PAE), which is the interval in hours between time melatonin and endogenous onset. When PAE was plotted against pretreatment (i.e. slightly than 24.0 h) period (tau), fitted regression line revealed significant correlation, consistent previous findings on light rest-activity rodents [Pittendrigh Daan, J. Comp. Physiol., 106 (1976) 291-331].
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sci-hub.se 参考文章(10)
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