Expression of Acute Phase Protein, Glial Fibrillary Acidic Protein, Epithelial Cadherin, and S100 Protein in Brain Tissues from Natural Cases of Ovine Encephalitic Listeriosis.

摘要: Listeriosis is a disease that induced by infection with the Gram-positive bacterium Listeria monocytogenes. Much still unknown about pathogenesis of encephalitic listeriosis. We aimed to identify contribution glial fibrillary acidic protein (GFAP), epithelial cadherin (E-cadherin), S100, and acute-phase proteins (APPs) in pathogenesis, clinical preclinical diagnosis natural cases Of 1,325 Ossimi sheep, 64 were suspected having listeriosis from 2018 2020. Prospective cohort evaluation postmortem findings was performed, addition bacterial isolation, measurement APPs serum cerebrospinal fluid (CSF), histopathological immunohistochemical GFAP, E-cadherin. Infected sheep showed nervous symptoms ranging neck stretching complete paralysis. significantly increased CSF both clinically preclinically diseased animals; however, only animals. Histopathological revealed microabscesses, meningoencephalitis, perivascular cuffing brainstem infected sheep. Immunohistochemical investigations strong expression GFAP S100 necrotic areas negative The could be useful involved listeriosis; E-cadherin does not appear involved.