Emerging wet electrohydrodynamic approaches for versatile bioactive 3D interfaces

摘要: There is a compelling need for delicate nanomaterial design with various intricate functions and applications. Electrohydrodynamics applies electrostatic force to overcome the surface tension of liquid jet, shrinking jet through intrinsic jetting instability into submicron fibers or spheres, versatility from huge selection materials, feasibility extracellular matrix structure mimicry multi-compartmentalization tissue engineering drug delivery. The process typically involves collection drying at solid substrate, but introduction phase by replacing collector coagulation bath can introduce variety new opportunities both chemical physical functionalizations in one single step. so-called wet electrohydrodynamics an emerging technique that enables facile, homogeneous functionalization large area fibers/spheres. With thorough literature sweep, we herein highlight three main features integrated step electrospinning terms creating functional biomaterials: (i) fabrication 3D macrostructures, (ii) situ functionalization, (iii) tunable nano-topography. Through technique, has demonstrated great potential interdisciplinary research development interfaces materials pertinent applications all fields where secondary structured, desired. Among these, engineered biomaterials bridging science biology have already shown particular potential.