Bayesian sequential integration within a preclinical pharmacokinetic and pharmacodynamic modeling framework: Lessons learned
作者： Fabiola La Gamba , Tom Jacobs , Helena Geys , Thomas Jaki , Jan Serroyen
DOI: 10.1002/PST.1941
关键词:
摘要: The present manuscript aims to discuss the implications of sequential knowledge integration small preclinical trials in a Bayesian pharmacokinetic and pharmacodynamic (PK-PD) framework. While, at first sight, PK-PD framework seems be natural allow for integration, scope this paper is highlight some often-overlooked challenges while same time providing guidances many overwhelming choices that need made. Challenges as well opportunities will discussed are related impact (1) prior specification, (2) choice random effects, (3) type method. In addition, it shown how success strategy highly dependent on carefully chosen experimental design when analyzed.
sci-hub.se 参考文章(37)
Michael A. Lyons, Anne J. Lenaerts, Computational pharmacokinetics/pharmacodynamics of rifampin in a mouse tuberculosis infection model Journal of Pharmacokinetics and Pharmacodynamics. ,vol. 42, pp. 375- 389 ,(2015) , 10.1007/S10928-015-9419-Z
J. C. Wakefield, A. F. M. Smith, A. Racine-Poon, A. E. Gelfand, Bayesian Analysis of Linear and Non‐Linear Population Models by Using the Gibbs Sampler Applied statistics. ,vol. 43, pp. 201- 221 ,(1992) , 10.2307/2986121
David J. Lunn, Nicky Best, Andrew Thomas, Jon Wakefield, David Spiegelhalter, Bayesian analysis of population PK/PD models: general concepts and software. Journal of Pharmacokinetics and Pharmacodynamics. ,vol. 29, pp. 271- 307 ,(2002) , 10.1023/A:1020206907668
Joseph G. Ibrahim, Ming-Hui Chen, Yeongjin Gwon, Fang Chen, The power prior: theory and applications. Statistics in Medicine. ,vol. 34, pp. 3724- 3749 ,(2015) , 10.1002/SIM.6728
Ben Li, Zhaonan Sun, Qing He, Yu Zhu, Zhaohui S. Qin, Bayesian inference with historical data-based informative priors improves detection of differentially expressed genes Bioinformatics. ,vol. 32, pp. 682- 689 ,(2016) , 10.1093/BIOINFORMATICS/BTV631
Melanie A. Felmlee, Marilyn E. Morris, Donald E. Mager, Mechanism-Based Pharmacodynamic Modeling Methods in Molecular Biology. ,vol. 929, pp. 583- 600 ,(2012) , 10.1007/978-1-62703-050-2_21
Peter F Thall, Richard C Herrick, Hoang Q Nguyen, John J Venier, J Clift Norris, Effective sample size for computing prior hyperparameters in Bayesian phase I–II dose-finding: Clinical Trials. ,vol. 11, pp. 657- 666 ,(2014) , 10.1177/1740774514547397
Pu Li, Quoc Dong Vu, Identification of parameter correlations for parameter estimation in dynamic biological models BMC Systems Biology. ,vol. 7, pp. 91- 91 ,(2013) , 10.1186/1752-0509-7-91
V Shivva, J Korell, IG Tucker, SB Duffull, An approach for identifiability of population pharmacokinetic-pharmacodynamic models. CPT: Pharmacometrics & Systems Pharmacology. ,vol. 2, pp. 1- 9 ,(2013) , 10.1038/PSP.2013.25
S J Kathman, D H Williams, J P Hodge, M Dar, A Bayesian population PK-PD model of ispinesib-induced myelosuppression. Clinical Pharmacology & Therapeutics. ,vol. 81, pp. 88- 94 ,(2007) , 10.1038/SJ.CLPT.6100021