The Effect of Hydro-Alcoholic Extract of Nigella sativa on Bmp7 and Bmp8b Expression in Rats Fed with a High-Fat Diet
作者： Akram Yaghoobi , Keihan Ghatreh Samani , Effat Farrokhi
DOI: 10.5812/JJNPP.65662
关键词:
摘要: Background: Bone morphogenetic protein7 (BMP7) and bone protein 8b (BMP8b) can induce browning of white adipose tissue. Objectives: The present study aimed to investigate the antioxidative effects hydro-alcoholic extract Nigella sativa on repair oxidative damage caused by a high-fat diet. Also, Bmp7 Bmp8b gene expressions were investigated tissue rats then compared with metformin effects. Methods: Eighty divided into two groups prevention treatment; each set was four sub-groups based administered diet (i.e., ordinary, fat, metformin, sativa). Lipid profile, paraoxonase1, malondialdehyde (MDA), HDL, antioxidant capacity measured in serum samples, relative calculated Results: For both treatment sets, weight who received decreased more those normal group. or nigella also MDA increased, but total catalase group declined receiving rats, liver PON1 activity, capacity, second (P < 0.05). In set, expression increased groups, whereas it among didn’t influence expression. Conclusions: This demonstrated that has protective role against stress
kowsarpub.com参考文章(27)
Hugo Aebi, Catalase in vitro Methods in Enzymology. ,vol. 105, pp. 121- 126 ,(1984) , 10.1016/S0076-6879(84)05016-3
J. A. Timmons, K. Wennmalm, O. Larsson, T. B. Walden, T. Lassmann, N. Petrovic, D. L. Hamilton, R. E. Gimeno, C. Wahlestedt, K. Baar, J. Nedergaard, B. Cannon, Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 4401- 4406 ,(2007) , 10.1073/PNAS.0610615104
Gladys Block, Marion Dietrich, Edward P Norkus, Jason D Morrow, Mark Hudes, Bette Caan, Lester Packer, Factors Associated with Oxidative Stress in Human Populations American Journal of Epidemiology. ,vol. 156, pp. 274- 285 ,(2002) , 10.1093/AJE/KWF029
Hossein Hosseinzadeh, Siavash Parvardeh, Marjan Nassiri Asl, Hamid R. Sadeghnia, Toktam Ziaee, Effect of thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus. Phytomedicine. ,vol. 14, pp. 621- 627 ,(2007) , 10.1016/J.PHYMED.2006.12.005
César Sánchez R, Carolina Ibáñez, Julieta Klaassen, Obesidad y Cancer: La tormenta perfecta Revista Medica De Chile. ,vol. 142, pp. 211- 221 ,(2014) , 10.4067/S0034-98872014000200010
N.S. Lobato, F.P. Filgueira, G.N. Hagihara, E.H. Akamine, J.R. Pariz, R.C. Tostes, M.H.C. Carvalho, Z.B. Fortes, Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats. Life Sciences. ,vol. 90, pp. 228- 235 ,(2012) , 10.1016/J.LFS.2011.11.005
Can Liu, Meng-yue Hu, Mian Zhang, Feng Li, Jia Li, Ji Zhang, Ying Li, Hai-fang Guo, Ping Xu, Li Liu, Xiao-dong Liu, Association of GLP-1 secretion with anti-hyperlipidemic effect of ginsenosides in high-fat diet fed rats Metabolism. ,vol. 63, pp. 1342- 1351 ,(2014) , 10.1016/J.METABOL.2014.06.015
Mariëtte R. Boon, Sjoerd A. A. van den Berg, Yanan Wang, Jan van den Bossche, Sofia Karkampouna, Matthias Bauwens, Marijke De Saint-Hubert, Geertje van der Horst, Slobodan Vukicevic, Menno P. J. de Winther, Louis M. Havekes, J. Wouter Jukema, Jouke T. Tamsma, Gabri van der Pluijm, Ko Willems van Dijk, Patrick C. N. Rensen, BMP7 Activates Brown Adipose Tissue and Reduces Diet-Induced Obesity Only at Subthermoneutrality PLoS ONE. ,vol. 8, pp. e74083- ,(2013) , 10.1371/JOURNAL.PONE.0074083
J Beltowski, Leptin decreases plasma paraoxonase 1 (PON1) activity and induces oxidative stress: the possible novel mechanism for proatherogenic effect of chronic hyperleptinemia Atherosclerosis. ,vol. 170, pp. 21- 29 ,(2003) , 10.1016/S0021-9150(03)00236-3
Hanene Jrah Harzallah, Rahma Grayaa, Wafa Kharoubi, Aya Maaloul, Mohamed Hammami, Touhami Mahjoub, Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis Oxidative Medicine and Cellular Longevity. ,vol. 2012, pp. 854065- 854065 ,(2012) , 10.1155/2012/854065