Docosahexaenoic acid and arachidonic acid enhance growth with no adverse effects in preterm infants fed formula

摘要: Abstract Objective: To determine if docosahexaenoic acid (DHA) and arachidonic (ARA) supplementation influences growth or visual acuity of formula-fed premature infants. Study design: Double-blind, multi-center study 194 infants given preterm formula with no DHA ARA (control), 0.15% energy DHA, 0.14% + 0.27% from single-cell triglycerides for at least 28 days then fed term (no ARA) to 57 weeks postmenstrual age (PMA), 90 breast-fed as reference. Results: Infants DHA+ARA gained weight significantly faster (post-hoc analysis) during feeding than control (34.7 vs. 30.7 g/d) had weights weight:length ratios not different 48 PMA. lower body Red blood cell phosphatidylethanolamine was correlated gain length 40, 48, PMA ( r = 0.19 0.24, P =.004-.02). Providing the period effect on subsequent incidence adverse events. Conclusions: Feeding enhances in evidence effects. (J Pediatr 2002;140:547-54)