Salmonella enterica serovar Typhi live vector vaccines finally come of age.
作者： James E Galen , Marcela F Pasetti , Sharon Tennant , Patricia Ruiz‐Olvera , Marcelo B Sztein
DOI: 10.1038/ICB.2009.31
关键词:
摘要: Attenuated Salmonella Typhi vaccine strains hold great promise as live vectors for presentation of foreign antigens from unrelated bacterial, viral and parasitic pathogens to the immune system. Although this approach has proved quite successful in experimental animal models for eliciting antigen‐specific mucosal, humoral and cellular responses, results have been disappointing for clinical trials carried out thus far. We hypothesize that the paucity of human responses to foreign antigens delivered by live vectors suggests that the strains and …
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