Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma.
作者： M Kawano , H Tanaka , H Ishikawa , M Nobuyoshi , K Iwato
DOI: 10.1182/BLOOD.V73.8.2145.2145
关键词:
摘要: Recombinant interleukin 1 alpha (rIL-1 alpha) augmented proliferation of freshly isolated myeloma cells as well B-cell stimulatory factor 2 (BSF-2)/interleukin-6 (IL-6). IL-1 alpha-induced was partially inhibited by anti-IL-6 antibody. In the culture supernatants rIL-1 alpha-stimulated cells, IL-6 activities, which were measured using an IL-6-dependent murine hybridoma clone, MH60.BSF2, increased, when compared with those in nonstimulated cells. Furthermore, messenger RNA (mRNA) expression also alpha- stimulated Therefore stimulates to produce IL-6, consequently augments Thus, can accelerate autocrine growth through IL-6.
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