Gelation of photopolymerized hyaluronic acid grafted with glycidyl methacrylate

摘要: Abstract Experiments have tracked the ambient gelation of a series hydrophilic hyaluronic acid (HA) resins grafted with glycidyl methacrylate (GM) and photopolymerized as function dose. The resin mixtures range in GMHA concentration between 0.5 1.5% w/w phosphate buffered saline (PBS). Illuminated at 20 mW/cm 2 , dynamic viscosity (η(t)) has been characterized using Boltzmann log-sigmoidal model. A gelled ~ 10 Pa s was determined 0.5% which rose to ~ 50 Pa s or above 1% w/w. More curing agent marginally increased gel each concentration. Time constants associated advancement were shortest [GMHA] = 1.0%; higher concentrations are attributed lower quantum efficiency when illuminated. Subsequent frequency sweeps replicated already published work similar GHMA PBS. G′ values ranged from 100 500 Pa over formulation expected sensitivity Overall, sigmoidal model represented this advancing data well, further analysis physical significance these parameters may help understanding photopolymerization complicated more broadly.