Fluid overload at initiation of renal replacement therapy is associated with lack of renal recovery in patients with acute kidney injury

摘要: Background. Patients with acute kidney injury (AKI) requiring initiation of renal replacement therapy (RRT) have poor short- and long-term outcomes, including the development dialysis dependence. Currently, little is known about what factors may predict recovery in this population. Methods. We conducted a single-center, retrospective analysis 170 hospitalized adult patients AKI attributed to tubular necrosis who required inpatient RRT. Data collection included patient characteristics, laboratory data, details hospital course degree fluid overload at RRT initiation. The primary outcome was function independence. Results. Within 1 year initiation, 35.9% (61/170) reached end point recovery. median (interquartile range) duration 11 (3–33) days 83.6% (51/61) recovered prior discharge. Recovering had significantly less time compared non-recovering (3.5 versus 9.3%, P ¼ 0.004). In multivariate Cox proportional hazard regression analysis, rise percent remained significant negative predictor (hazard ratio 0.97, 95% confidence interval 0.95–1.00, 0.024). Conclusions. AKI, higher predicts worse year. Clinical trials are needed determine whether interventions targeting improve outcomes.