Application of prothrombin complex concentrate for reversal of direct oral anticoagulants in clinical practice: indications, patient characteristics and clinical outcomes compared to reversal of vitamin K antagonists

摘要: Prothrombin complex concentrate (PCC) is widely used to reverse the action of direct oral anticoagulants (DOACs) in accordance with current guidelines and because a lack specific reversal agents. Indications, clinical characteristics patient outcomes patients might differ comparison vitamin K antagonists where PCC well established. Our cohort study explores characteristics, indications for all DOAC receiving at our university emergency department from 01.06.2012 01.07.2017, on VKA. Out 199,982 consultations, we studied 346 who were given either (n = 74) or VKA (n = 272). The most common reason treatment was acute bleeding; 86.7% both groups. 37.3% bleeding traumatic (p = 0.666). frequent location intracranial (61.6%, p = 0.881). Gastrointestinal more often found group (18.9% vs. 8.8%, p = 0.014). More erythrocyte concentrates (ECs) blood transfusion (p = 0.014). Tranexamic acid than (28.4% 7.4%, p < 0.001). No significant differences following outcomes: in-hospital mortality, ICU stay, length stay hospital. In treated patients, applied gastrointestinal received higher numbers ECs as tranexamic acid. observed regard important outcomes.