Effects of Cardiac Glycosides on Vascular System

摘要: The finding that the digitalis-induced stimulation of force contraction normal heart is not translated into an increase in cardiac output, suggests possible extracardiac vascular effects glycosides. A substantial body evidence has now been accumulated to indicate actions digitalis glycosides are limited heart. Indeed, it was at one time postulated primary action and direct on bed were responsible, part, for its therapeutic (Dock Tainter, 1930; Katz et al., 1938; McMichael Sharpey-Schafer, 1944; Lendle Mercker, 1961). Further, shown contractile response excised arterial venous strips enhanced presence (Brender 1969; Cow, 1911; Franklin, 1925; Leonard, 1957). More recently, considerable attention devoted clarification peripheral vasculature both animals humans. It purpose this chapter review these investigations order define alterations produced by drug resistance vessels (systemic arterioles) capacitance beds veins) circulation.