Regulation of BRCA1 transcription by specific single-stranded DNA binding factors.
作者： Sanjay Thakur , Tatsuya Nakamura , George Calin , Andrea Russo , Joseph F. Tamburrino
DOI: 10.1128/MCB.23.11.3774-3787.2003
关键词:
摘要: Since the majority of high-grade breast cancers express reduced levels BRCA1 mRNA, we investigated factors regulating transcription. Factors with specific affinity for previously identified positive regulatory region (PRR) in promoter were purified from whole-cell extracts. Identified proteins included replication protein A and a series related sense strand PRR. subset activated promoter. Identification these families represents an important step comprehension mechanisms responsible cancer development.
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