Stochastic fluctuations in gene expression in aging hippocampal neurons could be exacerbated by traumatic brain injury.

摘要: Traumatic brain injury (TBI) is a risk factor for age-related dementia and development of neurodegenerative disorders such as Alzheimer's disease that are associated with cognitive decline. The exact mechanism this unknown but we hypothesized TBI exacerbating changes in gene expression. Here, present evidence an animal model experimental increases stochastic We compared the variability expression several genes cell survival or death, among three groups laser capture microdissected hippocampal neurons from aging rat brains. increased fluctuations both dying surviving to naive neurons. Increases random, prosurvival prodeath could potentially alter death pathways after which may lead