SATELLITE CELL AND GROWTH FACTOR INVOLVEMENT IN SKELETAL MUSCLE GROWTH.

摘要: The activity of the satellite cell, discovered by Alexander Mauro, is fundamental importance in postnatal skeletal muscle development, adaptation to certain stimuli, and fiber regeneration following injury transplantation operations. There are numerous mitogens growth factors that influence cell proliferation differentiation vitro likely vivo. best understood purified fibroblast factor (FGF), insulin-like (IGF-I -II), transforming factor-beta (TGF-beta). Soluble extracts from injured chronically stretched also known be mitogenic yet purified. Skeletal hypertrophy, can viewed as points on a continuum with respect regulatory mechanisms myogenic growth. occurrence hyperplasia differs amongst some models activity-induced may reflect differences magnitude stimulus relative capacity fibers adapt. relationships between mechanical environmental events coincident an or role specific populations fertile areas for investigation. Insights these experiments will yield comprehensive understanding process at molecular, cellular, tissue levels, have implications development aging, health, disease, adaptation.