Pharmacokinetic study of orally administered RU 486 in non-pregnant women.
作者： Chang-hai He , Yong-en Shi , Zhi-hou Ye , Guo-qing Zhang , Nai-xiong Jiang
DOI: 10.1016/0010-7824(89)90052-8
关键词:
摘要: Abstract A method based on HPLC was devised for the estimation of RU 486 in blood and utilised to study pharmacokinetics a single dose 50 mg administered orally 12 women day 7 cycle. The rapidly absorbed with peak plasma concentration between 1 2 hours. Distribution also rapid (mean t α: 1.4h), whereas elimination slow β: 28.3 h). still detectable some at 72 h after administration. concentrations fitted equation two-compartment open model from which pharmacokinetic parameters were calculated. mean total clearance 3.0 1/h, comparison our data those published studies suggests that Chinese are similar other populations.
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