Control of the Acute Phase Response: SERUM C-REACTIVE PROTEIN KINETICS AFTER ACUTE MYOCARDIAL INFARCTION
作者： Irving Kushner , Martin L. Broder , David Karp
DOI: 10.1172/JCI108932
关键词:
摘要: Abstract In order to investigate the magnitude and kinetics of C-reactive protein (CRP) response after differing degrees tissue injury, we studied changes in serum concentration this acute phase 19 patients mild or extensive myocardial infarction. An increase CRP was seen all patients. The rate found be exponential, with a mean hourly constant for entire group 0.085 (doubling time, 8.2 h). Patients infarction attained levels about 4 times as great did No difference could shown between these groups, greater former resulting principally from more protracted period rise concentration. A lag before began noted only 13 whom assessed. 7 10 presumed unstable angina (coronary insufficiency) showed no concentration, while small 3 data suggest that such infarction, rapidly leads acceleration synthesis CRP, duration is related extent injury.
sci-hub.st 参考文章(20)
A. S. Tavill, R. Hoffenberg, Turnover of Plasma Proteins Springer, Boston, MA. pp. 107- 144 ,(1976) , 10.1007/978-1-4684-2679-3_4
Gewurz H, Claus Dr, Osmand Ap, Radioimmunoassay of human C-reactive protein and levels in normal sera. Journal of Laboratory and Clinical Medicine. ,vol. 87, pp. 120- ,(1976)
Thomas A. Waldmann, Warren Strober, Metabolism of Immunoglobulins Progress in allergy. ,vol. 13, pp. 1- 110 ,(1969) , 10.1159/000385919
R.F. Mortensen, D. Braun, H. Gewurz, Effects of C-reactive protein on lymphocyte functions Cellular Immunology. ,vol. 28, pp. 59- 68 ,(1977) , 10.1016/S0008-8749(77)80006-3
Co. Kindmark, J. I. Thorell, Quantitative Determination of Individual Serum Proteins by Radio-electroimmuno and Use of 125I-Labelled Antibodies (Application to C-reactive Protein) Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 124, pp. 49- 53 ,(1972) , 10.3109/00365517209102750
Irving Kushner, Jo Anne Somerville, Estimation of the molecular size of C-reactive protein and CX-reactive protein in serum. Biochimica et Biophysica Acta. ,vol. 207, pp. 105- 114 ,(1970) , 10.1016/0005-2795(70)90140-6
Adolph J. Boltax, Edward E. Fischel, Serologic tests for inflammation The American Journal of Medicine. ,vol. 20, pp. 418- 427 ,(1956) , 10.1016/0002-9343(56)90127-9
Lars-Åke Nilsson, Comparative testing of precipitation methods for quantitation of C-reactive protein in blood serum. Apmis. ,vol. 73, pp. 129- 144 ,(2009) , 10.1111/J.1699-0463.1968.TB00486.X
J. Hurlimann, G. J. Thorbecke, G. M. Hochwald, THE LIVER AS THE SITE OF C-REACTIVE PROTEIN FORMATION Journal of Experimental Medicine. ,vol. 123, pp. 365- 378 ,(1966) , 10.1084/JEM.123.2.365
Norman J. Hochella, Sidney Weinhouse, Automated assay of lactate dehydrogenase in urine Analytical Biochemistry. ,vol. 13, pp. 322- 335 ,(1965) , 10.1016/0003-2697(65)90201-0